Stability Indicating HPLC-ECD Method for the Analysis of Clarithromycin in Pharmaceutical Dosage Forms: Method Scaling versus Re-Validation
An isocratic high-performance liquid chromatographic method using electrochemical detection (HPLC-ECD) for the quantitation of clarithromycin here (CLA) was developed using Response Surface Methodology (RSM) based on a Central Composite Design (CCD).The method was validated using International Conference on Harmonization (ICH) guidelines with an an